Indapamide, Manufacturer of Indapamide, CAS No 26807–65

Indapamide

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CAS No .	26807–65–8
Chemical Name	4-chloro-N-[(2RS)-2-methyl-2,3-dihydro1Hindol-1-yl]- 3- sulphamoylbenzamide
Non propriety Names	------
Molecular Formula	C₁₆H₁₆ClN₃O₃S
Molecular Weight	365.8
PRODUCT SPECIFICATION
Description	White or almost white powder.
Solubilit	Practically insoluble in water , soluble in alcohol ,acetonitrile, ethyl acetate
Identification i) IR ii )UV Absorption	To comply To comply positively ( Absorption max. at 242nm , 279nm & 287 nm )
Melting Point	Melts bet. 167 ⁰ C -170 ⁰ C
LOD (at 105 C 4hr.)	NMT 3.0 %
Sulphated ash	NMT 0.1 %
Chromatographic Purity by TLC	No secondary spot is more than 0.5% The sum of the all secondary spots is NMT 2.0%
Residual organic solvents. Isopropyl alcohol Toluene Acetone (AS PER USP 31 SUPPLIMENT 2 JULY08)	NMT 1000 ppm NMT 800 ppm NMT 400 ppm
Related substance By HPLC	Methylnitrosoindoline Not more than 5 ppm Indapamide impurity B NMT 0.3% Sum of all Impurities NMT 0.5%
Assay by HPLC	98.0 % To 101.0 % w/w (ODB)
Therapeutic Category of these Drugs :- Diuretic, Antihypertensive